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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:27928
Term: parathion
Definition: An organothiophosphate insecticide that has formula C10H14NO5PS.
Chemical ID: MESH:D010278
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2d4affects metabolic processingISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 protein affects the metabolism of ParathionPMID:12669189
Cyp2d4increases expressionISOCyp2d22 (Mus musculus)6480464CTDParathion results in increased expression of CYP2D22 mRNAPMID:34813904
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