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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620555
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mt-nd1
Name: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mt-nd1decreases response to substanceISOMT-ND1 (Homo sapiens)6480464CTDND1 protein mutant form results in decreased susceptibility to ParaquatPMID:27449621
Mt-nd1increases expressionISOMT-ND1 (Homo sapiens)6480464CTDParaquat results in increased expression of ND1 mRNAPMID:34097952
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