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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620410
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ltb4r
Name: leukotriene B4 receptor
Acc ID: CHEBI:15647
Term: leukotriene B4
Definition: A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. It is a lipid mediator of inflammation that is generated from arachidonic acid via the 5-lipoxygenase pathway.
Chemical ID: MESH:D007975
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ltb4raffects bindingISOLTB4R (Homo sapiens)6480464CTDLeukotriene B4 analog binds to LTB4R1 proteinPMID:11006272
Ltb4raffects response to substanceISOLtb4r1 (Mus musculus)6480464CTDLTB4R1 protein affects the susceptibility to Leukotriene B4PMID:10934232
Ltb4rmultiple interactionsISOLTB4R (Homo sapiens)6480464CTDLeukotriene B4 binds to and results in increased activity of LTB4R protein; LY 255283 analog inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]; LY 255283 inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]; LY 293111 inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]PMID:7473568
Ltb4rmultiple interactionsISOLtb4r1 (Mus musculus)6480464CTD[SC 41930 binds to and results in decreased activity of LTB4R protein] which results in decreased abundance of Leukotriene B4; Leukotriene B4 binds to and affects the activity of LTB4R1 proteinPMID:10934232 PMID:8014878
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