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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2decreases expressionEXP 6480464CTDEthanol results in decreased expression of NFE2L2 mRNA; Ethanol results in decreased expression of NFE2L2 proteinPMID:26460608 PMID:30372842 PMID:32151596 PMID:34346143
Nfe2l2multiple interactionsEXP 6480464CTD[Dietary Fats co-treated with Ethanol] results in decreased expression of NFE2L2 mRNA; [Fish Oils co-treated with Ethanol] results in increased expression of NFE2L2 mRNA; Arbutin inhibits the reaction [Ethanol results in decreased expression of NFE2L2 mRNA]; Ethanol inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] affects the localization of NFE2L2 protein]; Ethanol results in decreased expression of and affects the localization of NFE2L2 protein; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in decreased expression of NFE2L2 mRNA]; Oleanolic Acid inhibits the reaction [Ethanol results in decreased expression of NFE2L2 protein]; Oleanolic Acid promotes the reaction [Ethanol affects the localization of NFE2L2 protein]; p-coumaric acid inhibits the reaction [Ethanol results in decreased expression of NFE2L2 protein]; Silymarin inhibits the reaction [Ethanol results in decreased expression of NFE2L2 mRNA]PMID:17347304 PMID:25111957 PMID:26747958 PMID:30372842 PMID:32151596 PMID:34346143
Nfe2l2affects expressionISONfe2l2 (Mus musculus)6480464CTDEthanol affects the expression of NFE2L2 proteinPMID:35526736
Nfe2l2affects localizationISONFE2L2 (Homo sapiens)6480464CTDEthanol affects the localization of NFE2L2 proteinPMID:17433488 PMID:22530035
Nfe2l2affects response to substanceISONfe2l2 (Mus musculus)6480464CTDNFE2L2 protein affects the susceptibility to EthanolPMID:22627062 PMID:30248482
Nfe2l2decreases expressionISONFE2L2 (Homo sapiens)6480464CTDEthanol results in decreased expression of NFE2L2 mRNA; Ethanol results in decreased expression of NFE2L2 proteinPMID:30853489 PMID:34474091 PMID:35149083
Nfe2l2decreases expressionISONfe2l2 (Mus musculus)6480464CTDEthanol results in decreased expression of NFE2L2 mRNAPMID:15513904 PMID:34995708
Nfe2l2decreases response to substanceISONFE2L2 (Homo sapiens)6480464CTDNFE2L2 protein results in decreased susceptibility to EthanolPMID:23994065
Nfe2l2increases activityISONfe2l2 (Mus musculus)6480464CTDEthanol results in increased activity of NFE2L2 proteinPMID:30114225 PMID:30203046
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDEthanol results in increased expression of NFE2L2 proteinPMID:23994065
Nfe2l2increases expressionISONfe2l2 (Mus musculus)6480464CTDEthanol results in increased expression of NFE2L2 proteinPMID:22996800 PMID:23994065 PMID:25449124
Nfe2l2increases response to substanceISONfe2l2 (Mus musculus)6480464CTDNFE2L2 gene mutant form results in increased susceptibility to EthanolPMID:34116071
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTD[2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Ethanol co-treated with Benzo(a)pyrene]] which results in increased expression of NFE2L2 mRNA; [[Ethanol affects the activity of CYP2E1 protein] which affects the localization of NFE2L2 protein] which results in increased expression of CYP2A6; [Ethanol affects the activity of CYP2E1 protein] which affects the localization of NFE2L2 protein; [Ethanol affects the localization of NFE2L2 protein] which results in increased expression of CYP2A6; [Ethanol co-treated with Benzo(a)pyrene] results in increased expression of NFE2L2 mRNA; [lucidone co-treated with Ethanol] results in increased expression of NFE2L2 mRNA; Gallic Acid inhibits the reaction [Ethanol results in decreased expression of NFE2L2 mRNA]; Gallic Acid inhibits the reaction [Ethanol results in decreased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [Gallic Acid inhibits the reaction [Ethanol results in increased activity of GPT protein]]; NFE2L2 protein affects the reaction [Gallic Acid inhibits the reaction [Ethanol results in increased expression of RIPK3 mRNA]]; NFE2L2 protein affects the reaction [Gallic Acid inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]]; NFE2L2 protein inhibits the reaction [Ethanol results in increased abundance of Reactive Oxygen Species]; NFE2L2 protein inhibits the reaction [Ethanol results in increased activity of GPT protein]; NFE2L2 protein inhibits the reaction [Ethanol results in increased cleavage of and results in increased activity of CASP3 protein]; NFE2L2 protein inhibits the reaction [Ethanol results in increased expression of CASP3 protein modified form]; NFE2L2 protein inhibits the reaction [Ethanol results in increased expression of RIPK3 mRNA]; NFE2L2 protein inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]; NFE2L2 protein promotes the reaction [Ethanol results in increased expression of and results in increased activity of CAT protein]; NFE2L2 protein promotes the reaction [Ethanol results in increased expression of and results in increased activity of SOD1 protein]; NFE2L2 protein promotes the reaction [Ethanol results in increased expression of CAT mRNA]; NFE2L2 protein promotes the reaction [Ethanol results in increased expression of GPX3 mRNA]; NFE2L2 protein promotes the reaction [Ethanol results in increased expression of GPX3 protein]; NFE2L2 protein promotes the reaction [Ethanol results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [Ethanol results in increased expression of NQO1 protein]; NFE2L2 protein promotes the reaction [Ethanol results in increased expression of SOD1 mRNA]; pterostilbene inhibits the reaction [Ethanol results in decreased expression of NFE2L2 protein]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of NFE2L2 protein]]; Staurosporine inhibits the reaction [Ethanol affects the localization of NFE2L2 protein]; U 0126 inhibits the reaction [Ethanol affects the localization of NFE2L2 protein]PMID:22484158 PMID:22530035 PMID:23994065 PMID:30853489 PMID:34474091 PMID:35412187
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Plant Extracts co-treated with Ethanol] results in increased expression of and affects the localization of NFE2L2 protein]; [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of NFE2L2 mRNA; [ethylene dichloride co-treated with Ethanol] results in increased expression of NFE2L2 mRNA; [ethylene dichloride co-treated with Ethanol] results in increased expression of NFE2L2 protein; [Plant Extracts co-treated with Ethanol] results in increased expression of and affects the localization of NFE2L2 protein; allyl sulfide inhibits the reaction [[ethylene dichloride co-treated with Ethanol] results in increased expression of NFE2L2 protein]; diallyl disulfide inhibits the reaction [Ethanol affects the expression of NFE2L2 protein]; Ethanol inhibits the reaction [NFE2L2 gene mutant form results in decreased expression of FGF21 protein]; Ethanol inhibits the reaction [NFE2L2 gene mutant form results in increased expression of PPARA protein]; Ethanol promotes the reaction [Dietary Fats results in decreased expression of NFE2L2 protein]; Ethanol promotes the reaction [ethylene dichloride results in increased expression of NFE2L2 mRNA]; Ethanol results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of COL1A1 protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of FN1 protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of RELA protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of TNF protein]]; NFE2L2 gene mutant form inhibits the reaction [Ethanol results in increased expression of ADH1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Ethanol results in increased expression of CAT mRNA]; NFE2L2 gene mutant form inhibits the reaction [Ethanol results in increased expression of PPARA protein]; NFE2L2 gene mutant form inhibits the reaction [Ethanol results in increased expression of PPARG protein]; NFE2L2 gene mutant form promotes the reaction [Ethanol results in decreased expression of ALDH1A1 mRNA]; NFE2L2 gene mutant form promotes the reaction [Ethanol results in increased cleavage of PARP1 protein]; NFE2L2 protein affects the reaction [Ethanol results in increased abundance of Fatty Acids, Nonesterified]; NFE2L2 protein affects the reaction [Ethanol results in increased abundance of Triglycerides]; NFE2L2 protein affects the reaction [Ethanol results in increased activity of GPT protein]; NFE2L2 protein affects the reaction [Ethanol results in increased expression of and results in increased activity of CYP2A5 protein]; NFE2L2 protein affects the reaction [Ethanol results in increased expression of CYP2A5 protein]; NFE2L2 protein affects the reaction [Ethanol results in increased expression of INS1 protein]; NFE2L2 protein affects the reaction [Ethanol results in increased expression of SREBF1 mRNA]; pyrazolanthrone inhibits the reaction [[Plant Extracts co-treated with Ethanol] results in increased expression of and affects the localization of NFE2L2 protein]; SB 203580 promotes the reaction [[Plant Extracts co-treated with Ethanol] results in increased expression of and affects the localization of NFE2L2 protein]PMID:22552773 PMID:22627062 PMID:25449124 PMID:27837167 PMID:28131861 PMID:30248482 PMID:30517762 PMID:30664321 PMID:34116071 PMID:35526736 PMID:35863473 PMID:37150348
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