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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620266
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc4
Name: ATP binding cassette subfamily C member 4
Acc ID: CHEBI:9927
Term: valsartan
Definition: A monocarboxylic acid amide consisting of L-valine in which the amino hydrogens have been replaced by a pentanoyl and a [2'-(1H-tetrazol-5-yl)biphenyl]-4-yl]methyl group. It exhibits antihypertensive activity.
Chemical ID: MESH:C081489
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc4multiple interactionsEXP 6480464CTD[adefovir co-treated with Probenecid co-treated with Valsartan] affects the expression of ABCC4 protein; Valsartan inhibits the reaction [Purines analog results in decreased expression of MRP4 protein]PMID:35114312 PMID:36464070
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