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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620260
Species: Rattus norvegicus
RGD Object: Gene
Symbol: S100a3
Name: S100 calcium binding protein A3
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
S100a3affects response to substanceISOS100A3 (Homo sapiens)6480464CTDS100A3 protein affects the susceptibility to FluorouracilPMID:15352031
S100a3decreases expressionISOS100A3 (Homo sapiens)6480464CTDFluorouracil results in decreased expression of S100A3 proteinPMID:15352031
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