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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62011
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igbp1
Name: immunoglobulin binding protein 1
Acc ID: CHEBI:6925
Term: microcystin-LR
Definition: A microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. Produced by the cyanobacterium Microcystis aeruginosa, it is the most studied of the microcystins.
Chemical ID: MESH:C057862
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igbp1affects response to substanceISOIGBP1 (Homo sapiens)6480464CTDIGBP1 protein affects the susceptibility to cyanoginosin LRPMID:26784437
Igbp1increases response to substanceISOIGBP1 (Homo sapiens)6480464CTDIGBP1 protein results in increased susceptibility to cyanoginosin LRPMID:29984889
Igbp1multiple interactionsISOIGBP1 (Homo sapiens)6480464CTD[IGBP1 protein results in increased susceptibility to cyanoginosin LR] which affects the expression of PPP2CA protein modified form; [IGBP1 protein results in increased susceptibility to cyanoginosin LR] which affects the expression of VASP protein modified form; [IGBP1 protein results in increased susceptibility to cyanoginosin LR] which results in increased expression of EZR protein modified form; [IGBP1 protein results in increased susceptibility to cyanoginosin LR] which results in increased expression of PPP2CA protein; [IGBP1 protein results in increased susceptibility to cyanoginosin LR] which results in increased phosphorylation of MAPK1 protein; [IGBP1 protein results in increased susceptibility to cyanoginosin LR] which results in increased phosphorylation of MAPK3 protein; [IGBP1 protein results in increased susceptibility to cyanoginosin LR] which results in increased phosphorylation of MAPK8 protein; [IGBP1 protein results in increased susceptibility to cyanoginosin LR] which results in increased phosphorylation of MAPK9 protein; cyanoginosin LR inhibits the reaction [IGBP1 protein binds to PPP2CA protein]; cyanoginosin LR inhibits the reaction [PPP2CA protein binds to IGBP1 protein]PMID:27393157 PMID:29984889
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