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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62010
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcr5
Name: C-X-C motif chemokine receptor 5
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcr5affects methylationISOCXCR5 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of CXCR5 promoterPMID:27901495
Cxcr5decreases expressionISOCxcr5 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CXCR5 mRNAPMID:21569818 PMID:22228805 PMID:22610609
Cxcr5increases expressionISOCXCR5 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of CXCR5 mRNA; Benzo(a)pyrene results in increased expression of CXCR5 proteinPMID:20064835 PMID:30453624
Cxcr5multiple interactionsISOCXCR5 (Homo sapiens)6480464CTDAHR protein affects the reaction [Benzo(a)pyrene results in increased expression of CXCR5 mRNA]PMID:20064835
Cxcr5multiple interactionsISOCxcr5 (Mus musculus)6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CXCR5 mRNAPMID:27858113
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