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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62001
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Muc5ac
Name: mucin 5AC, oligomeric mucus/gel-forming
Acc ID: CHEBI:28666
Term: leukotriene D4
Definition: A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and a L-cysteinylglycinyl group at position 6 (6R).
Chemical ID: MESH:D017998
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Muc5acincreases expressionEXP 6480464CTDLeukotriene D4 results in increased expression of MUC5AC mRNA; Leukotriene D4 results in increased expression of MUC5AC proteinPMID:12654629
Muc5acmultiple interactionsEXP 6480464CTD[IL13 protein results in increased abundance of Leukotriene D4] which results in increased secretion of MUC5AC protein; verlukast inhibits the reaction [Leukotriene D4 results in increased expression of MUC5AC mRNA]; verlukast inhibits the reaction [Leukotriene D4 results in increased expression of MUC5AC protein]PMID:12654629
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