GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gch1 | affects abundance | ISO | Gch1 (Mus musculus) | 6480464 | CTD | GCH1 protein affects the abundance of sapropterin | PMID:21963838 | Gch1 | decreases abundance | ISO | GCH1 (Homo sapiens) | 6480464 | CTD | GCH1 mutant form results in decreased abundance of sapropterin | PMID:25041251 | Gch1 | increases chemical synthesis | ISO | GCH1 (Homo sapiens) | 6480464 | CTD | GCH1 protein results in increased chemical synthesis of sapropterin | PMID:14551046 | Gch1 | multiple interactions | ISO | GCH1 (Homo sapiens) | 6480464 | CTD | EPO protein inhibits the reaction [GCH1 mutant form results in decreased abundance of sapropterin] | PMID:25041251 | Gch1 | multiple interactions | ISO | Gch1 (Mus musculus) | 6480464 | CTD | [GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin; [Resveratrol results in increased expression of GCH1 mRNA] which results in increased abundance of sapropterin; EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]; GCH1 gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin | PMID:20610621 PMID:25490417 | |
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