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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61992
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gch1
Name: GTP cyclohydrolase 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gch1increases expressionEXP 6480464CTDresveratrol results in increased expression of GCH1 proteinPMID:17666920
Gch1multiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [resveratrol results in increased expression of GCH1 protein]PMID:17666920
Gch1increases expressionISOGCH1 (Homo sapiens)6480464CTDresveratrol results in increased expression of GCH1PMID:20610621
Gch1increases expressionISOGch1 (Mus musculus)6480464CTDresveratrol results in increased expression of GCH1 mRNAPMID:20610621
Gch1multiple interactionsISOGch1 (Mus musculus)6480464CTD[resveratrol results in increased expression of GCH1 mRNA] which results in increased abundance of sapropterinPMID:20610621
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