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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619831
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fas
Name: Fas cell surface death receptor
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fasdecreases expressionEXP 6480464CTDDexamethasone results in decreased expression of FAS mRNA; Dexamethasone results in decreased expression of FAS proteinPMID:11778176
Fasdecreases expressionISOFas (Mus musculus)6480464CTDDexamethasone results in decreased expression of FAS mRNAPMID:21041162
Fasincreases expressionISOFAS (Homo sapiens)6480464CTDDexamethasone results in increased expression of FAS proteinPMID:14633444
Fasincreases expressionISOFas (Mus musculus)6480464CTDDexamethasone results in increased expression of FAS mRNAPMID:12513834 PMID:25900201
Fasmultiple interactionsISOFAS (Homo sapiens)6480464CTDFAS protein inhibits the reaction [Dexamethasone results in increased activity of CASP3 protein]PMID:16164824
Fasmultiple interactionsISOFas (Mus musculus)6480464CTD[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of FAS mRNA; [Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of FAS mRNA; EGF protein inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of FAS mRNA]; pentagalloylglucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of FAS mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of FAS mRNA]PMID:16054899 PMID:30721698
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