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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619791
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bub1b
Name: BUB1 mitotic checkpoint serine/threonine kinase B
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bub1bincreases phosphorylationISOBUB1B (Homo sapiens)6480464CTDArsenic Trioxide results in increased phosphorylation of BUB1B proteinPMID:19371599
Bub1bmultiple interactionsISOBUB1B (Homo sapiens)6480464CTD17-(dimethylaminoethylamino)-17-demethoxygeldanamycin promotes the reaction [Arsenic Trioxide results in increased phosphorylation of BUB1B protein]; [Arsenic Trioxide co-treated with Paclitaxel] promotes the reaction [BUB1B protein binds to CDC20 protein]; [Arsenic Trioxide co-treated with Paclitaxel] results in increased expression of BUB1B protein modified form; KNK 437 promotes the reaction [Arsenic Trioxide results in increased phosphorylation of BUB1B protein]PMID:19371599 PMID:19781537
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