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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619713
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cnr2
Name: cannabinoid receptor 2
Acc ID: CHEBI:52392
Term: 2-arachidonoylglycerol
Definition: An endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol.
Chemical ID: MESH:C094503
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cnr2affects response to substanceISOCNR2 (Homo sapiens)6480464CTDCNR2 gene SNP affects the susceptibility to glyceryl 2-arachidonatePMID:20124950
Cnr2multiple interactionsISOCnr2 (Mus musculus)6480464CTDglyceryl 2-arachidonate binds to and results in increased activity of CNR2 proteinPMID:27194477
Cnr2multiple interactionsISOCNR2 (Homo sapiens)6480464CTD[GRK2 protein co-treated with glyceryl 2-arachidonate] promotes the reaction [CNR2 protein affects the localization of ARRB2 protein]; [SR 144528 binds to and results in increased activity of CNR2 protein] inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CXCL8 protein]; CNR2 protein affects the reaction [glyceryl 2-arachidonate results in increased expression of CXCL8 protein]; CNR2 protein affects the reaction [glyceryl 2-arachidonate results in increased transport of Calcium]; glyceryl 2-arachidonate binds to and results in increased activity of CNR2 protein; glyceryl 2-arachidonate promotes the reaction [CNR2 protein affects the localization of ARRB1 protein]; glyceryl 2-arachidonate promotes the reaction [CNR2 protein affects the localization of ARRB2 protein]; Pertussis Toxin inhibits the reaction [CNR2 protein affects the reaction [glyceryl 2-arachidonate results in increased transport of Calcium]]; SR 144528 inhibits the reaction [CNR2 protein affects the reaction [glyceryl 2-arachidonate results in increased transport of Calcium]]PMID:10617657 PMID:15115777 PMID:30102254 PMID:31024316
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