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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619563
Species: Homo sapiens
RGD Object: Gene
Symbol: ERBB2
Name: erb-b2 receptor tyrosine kinase 2
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ERBB2affects response to substanceEXP 6480464CTDERBB2 affects the susceptibility to arsenitePMID:31773452
ERBB2decreases expressionEXP 6480464CTDarsenite results in decreased expression of ERBB2 mRNA; arsenite results in decreased expression of ERBB2 proteinPMID:31646340 PMID:31934280
ERBB2multiple interactionsEXP 6480464CTD[arsenite co-treated with tetrandrine] results in decreased expression of ERBB2 protein; arsenite results in increased expression of and results in increased phosphorylation of ERBB2 protein; ERBB2 affects the reaction [arsenite results in decreased expression of CDH1 protein]; ERBB2 affects the reaction [arsenite results in decreased expression of IL6 protein]; ERBB2 affects the reaction [arsenite results in decreased expression of NDRG1 protein]; ERBB2 affects the reaction [arsenite results in increased expression of CCND1 protein]; ERBB2 affects the reaction [arsenite results in increased expression of PCNA protein]; ERBB2 affects the reaction [arsenite results in increased expression of PTGS2 protein]; ERBB2 affects the reaction [arsenite results in increased secretion of CDH1 protein alternative form]; ERBB2 affects the reaction [arsenite results in increased secretion of EGF protein]; ERBB2 affects the reaction [arsenite results in increased secretion of TGFA protein]; Fulvestrant inhibits the reaction [arsenite results in decreased expression of ERBB2 mRNA]PMID:31646340 PMID:31773452 PMID:31934280
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