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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61805
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgf7
Name: fibroblast growth factor 7
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgf7decreases response to substanceISOFGF7 (Homo sapiens)6480464CTDFGF7 protein results in decreased susceptibility to Fluorouracil; FGF7 results in decreased susceptibility to FluorouracilPMID:18575591
Fgf7multiple interactionsISOFGF7 (Homo sapiens)6480464CTDFGFR2 inhibits the reaction [FGF7 results in decreased susceptibility to Fluorouracil]; FGFR2 protein alternative form inhibits the reaction [FGF7 protein results in decreased susceptibility to Fluorouracil]PMID:18575591
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