Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3935
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase family 1 member A1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a1affects expressionEXP 6480464CTDEstradiol affects the expression of UGT1A1 mRNAPMID:22389237 PMID:24777823
Ugt1a1increases expressionEXP 6480464CTDEstradiol results in increased expression of UGT1A1 mRNAPMID:31119341
Ugt1a1increases glucuronidationEXP 6480464CTDUGT1A1 protein results in increased glucuronidation of EstradiolPMID:31128210
Ugt1a1multiple interactionsEXP 6480464CTD[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA]; [bisphenol A co-treated with Estradiol] results in increased expression of UGT1A1 mRNA; [Progesterone co-treated with Estradiol] affects the expression of UGT1A1 mRNA; shikonin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol]PMID:22389237 PMID:24777823 PMID:26496021 PMID:31128210
Ugt1a1decreases activityISOUGT1A1 (Homo sapiens)6480464CTDEstradiol results in decreased activity of UGT1A1 proteinPMID:15378558
Ugt1a1decreases expressionISOUGT1A1 (Homo sapiens)6480464CTDEstradiol results in decreased expression of UGT1A1 mRNAPMID:15072547 PMID:17982697
Ugt1a1decreases glucuronidationISOUGT1A1 (Homo sapiens)6480464CTDUGT1A1 gene mutant form results in decreased glucuronidation of Estradiol analogPMID:17898154
Ugt1a1increases glucuronidationISOUGT1A1 (Homo sapiens)6480464CTDUGT1A1 protein results in increased glucuronidation of Estradiol; UGT1A1 protein results in increased glucuronidation of Estradiol analogPMID:15117964 PMID:15472229 PMID:15593333 PMID:15769885 PMID:16051636 PMID:17898154 PMID:25393417 PMID:27676153 PMID:30237061 PMID:30776358 PMID:31128210
Ugt1a1multiple interactionsISOUGT1A1 (Homo sapiens)6480464CTD[Cycloheximide co-treated with Estradiol] results in decreased expression of UGT1A1 mRNA; [Estradiol co-treated with TGFB1 protein] results in decreased expression of UGT1A1 mRNA; [Warfarin binds to and results in decreased activity of UGT1A1 protein] which results in decreased glucuronidation of Estradiol; Estradiol promotes the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; Fusidic Acid inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol]; shikonin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol]; Warfarin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol]PMID:15072547 PMID:15378558 PMID:25393417 PMID:27676153 PMID:30165855 PMID:31128210
Go Back to source page   Continue to Ontology report