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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3932
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ucp2
Name: uncoupling protein 2
Acc ID: CHEBI:16196
Term: oleic acid
Definition: An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.
Chemical ID: MESH:D019301
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ucp2decreases expressionEXP 6480464CTDOleic Acid results in decreased expression of UCP2 mRNAPMID:24349266
Ucp2increases expressionEXP 6480464CTDOleic Acid results in increased expression of UCP2 mRNAPMID:11341955 PMID:12588052
Ucp2multiple interactionsEXP 6480464CTD[Oleic Acid co-treated with Palmitic Acid co-treated with Ethanol] results in decreased expression of UCP2 protein; [Oleic Acid co-treated with Palmitic Acid] results in decreased expression of UCP2 mRNA; [Oleic Acid co-treated with Palmitic Acid] results in increased expression of UCP2 mRNA; [Oleic Acid co-treated with Palmitic Acid] results in increased expression of UCP2 protein; tetrabromobisphenol A promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of UCP2 mRNA]; tetrabromobisphenol A promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of UCP2 protein]; Triiodothyronine promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of UCP2 mRNA]; Triiodothyronine promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of UCP2 protein]PMID:25048947 PMID:26854922
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