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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3910
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tshb
Name: thyroid stimulating hormone subunit beta
Acc ID: CHEBI:18258
Term: 3,3',5-triiodo-L-thyronine
Definition: An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
Chemical ID: MESH:D014284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tshbdecreases expressionEXP 6480464CTDTriiodothyronine results in decreased expression of TSHB mRNAPMID:28167136 PMID:7827627
Tshbdecreases expressionISOTshb (Mus musculus)6480464CTDTriiodothyronine results in decreased expression of TSHB mRNAPMID:27420076 PMID:9092800
Tshbincreases secretionISOTSHB (Homo sapiens)6480464CTDTSHB protein results in increased secretion of TriiodothyroninePMID:11288978
Tshbmultiple interactionsISOTshb (Mus musculus)6480464CTD[Triiodothyronine co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in decreased expression of TSHB mRNA alternative formPMID:27420076
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