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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3858
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Thrb
Name: thyroid hormone receptor beta
Acc ID: CHEBI:146195
Term: 3-acetyldeoxynivalenol
Definition: A trichothecene mycotoxin that is deoxynivalenol acetylated on the oxygen at C-3. A skin and eye irritant, along with its 15-acetyl regioisomer and its parent deoxynivalenol it is considered among the most commonly and widely distributed cereal contaminants.
Chemical ID: MESH:C043247
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Thrbdecreases activityISOTHRB (Homo sapiens)6480464CTD3-acetyldeoxynivalenol results in decreased activity of THRB proteinPMID:27481073
Thrbmultiple interactionsISOTHRB (Homo sapiens)6480464CTD[15-acetyldeoxynivalenol co-treated with 3-acetyldeoxynivalenol co-treated with deoxynivalenol co-treated with zearalenol co-treated with Zearalenone] results in decreased activity of THRB proteinPMID:27481073
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