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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3767
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sult1a1
Name: sulfotransferase family 1A member 1
Acc ID: CHEBI:16836
Term: 4-nitrophenol
Definition: A member of the class of 4-nitrophenols that is phenol in which the hydrogen that is para to the hydroxy group has been replaced by a nitro group.
Chemical ID: MESH:C024836
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sult1a1increases sulfationEXP 6480464CTDSULT1A1 protein results in increased sulfation of 4-nitrophenolPMID:11181495
Sult1a1affects sulfationISOSULT1A1 (Homo sapiens)6480464CTDSULT1A1 gene polymorphism affects the sulfation of 4-nitrophenolPMID:15516026 PMID:16517757
Sult1a1increases metabolic processingISOSULT1A1 (Homo sapiens)6480464CTDSULT1A1 protein results in increased metabolism of 4-nitrophenolPMID:10623578
Sult1a1increases sulfationISOSULT1A1 (Homo sapiens)6480464CTDSULT1A1 protein results in increased sulfation of 4-nitrophenolPMID:11181495 PMID:14570759 PMID:15516026 PMID:15680679 PMID:16413005 PMID:16517757 PMID:19646966
Sult1a1multiple interactionsISOSULT1A1 (Homo sapiens)6480464CTD2,6-dichloro-4-nitrophenol inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]; 3,3'-diiodothyronine inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]; 4-nitrophenol inhibits the reaction [SULT1A1 protein results in decreased sulfation of bisphenol A]; acetonitrile inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]; Chlorophenols analog inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]; daidzein inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]; Dimethyl Sulfoxide inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]; Dimethylformamide inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]; Ethanol inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]; Genistein inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]; Methanol inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]; Polychlorinated Biphenyls analog inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]; Sodium Chloride inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]; Thyroxine inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]; Triiodothyronine inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]; Triiodothyronine, Reverse inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]PMID:11425650 PMID:12206822 PMID:14570759 PMID:15531517 PMID:16413005
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