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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2affects response to substanceISOSOD2 (Homo sapiens)6480464CTDSOD2 protein affects the susceptibility to tert-ButylhydroperoxidePMID:20107204
Sod2decreases expressionISOSOD2 (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in decreased expression of SOD2 proteinPMID:27050144 PMID:29128606
Sod2increases activityISOSod2 (Mus musculus)6480464CTDtert-Butylhydroperoxide results in increased activity of SOD2 proteinPMID:16704919
Sod2increases expressionISOSod2 (Mus musculus)6480464CTDtert-Butylhydroperoxide results in increased expression of SOD2 mRNAPMID:16704919
Sod2increases expressionISOSOD2 (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in increased expression of SOD2 mRNAPMID:15336504 PMID:16636651 PMID:17003459 PMID:27509014 PMID:31627909
Sod2increases response to substanceISOSod2 (Mus musculus)6480464CTDSOD2 gene mutant form results in increased susceptibility to tert-ButylhydroperoxidePMID:15182862
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTD3,4-dihydroxyphenyllactic acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of SOD2 protein]; [Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of SOD2 mRNA; LGM2605 promotes the reaction [tert-Butylhydroperoxide results in increased expression of SOD2 mRNA]; MT2A protein promotes the reaction [tert-Butylhydroperoxide results in increased expression of SOD2 mRNA]; Plant Extracts inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of SOD2 protein]; Quercetin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of SOD2 protein]; Resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of and results in increased acetylation of SOD2 protein]; SIRT3 mutant form inhibits the reaction [Resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of and results in increased acetylation of SOD2 protein]]; tert-Butylhydroperoxide results in decreased activity of and results in increased acetylation of SOD2 proteinPMID:16636651 PMID:25522270 PMID:27050144 PMID:29128606 PMID:31627909 PMID:35690295
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