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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3731
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod1
Name: superoxide dismutase 1
Acc ID: CHEBI:28918
Term: (R)-adrenaline
Definition: The R-enantiomer of adrenaline. It is a hormone secreted by the adrenal glands resulting in the 'fight-or-flight' response.
Chemical ID: MESH:D004837
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod1increases expressionEXP 6480464CTDEpinephrine results in increased expression of SOD1 proteinPMID:19464573
Sod1multiple interactionsEXP 6480464CTD[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of SOD1 proteinPMID:19464573
Sod1affects bindingISOSOD1 (Homo sapiens)6480464CTDEpinephrine binds to SOD1 protein mutant formPMID:23612299
Sod1increases activityISOSOD1 (Homo sapiens)6480464CTDEpinephrine results in increased activity of SOD1 proteinPMID:11163531
Sod1increases expressionISOSOD1 (Homo sapiens)6480464CTDEpinephrine results in increased expression of SOD1 mRNA; Epinephrine results in increased expression of SOD1 proteinPMID:11163531
Sod1multiple interactionsISOSOD1 (Homo sapiens)6480464CTD6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]; Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]; Vitamin E inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]PMID:11163531
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