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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3701
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a3
Name: solute carrier family 22 member 3
Acc ID: CHEBI:28918
Term: (R)-adrenaline
Definition: The R-enantiomer of adrenaline. It is a hormone secreted by the adrenal glands resulting in the 'fight-or-flight' response.
Chemical ID: MESH:D004837
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a3multiple interactionsEXP 6480464CTD[Corticosterone results in decreased activity of SLC22A3 protein] inhibits the reaction [Epinephrine results in increased abundance of Epinephrine metabolite]; [Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased abundance of EpinephrinePMID:19053318
Slc22a3increases uptakeISOSLC22A3 (Homo sapiens)6480464CTDSLC22A3 protein results in increased uptake of EpinephrinePMID:20858707
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