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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3698
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc1a3
Name: solute carrier family 1 member 3
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc1a3increases expressionEXP 6480464CTDEstradiol results in increased expression of SLC1A3 mRNA; Estradiol results in increased expression of SLC1A3 proteinPMID:19453300 PMID:29425760
Slc1a3multiple interactionsEXP 6480464CTDEstradiol inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of SLC1A3 protein]; Estradiol inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]; Estradiol inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]PMID:19453300 PMID:29425760
Slc1a3multiple interactionsISOSLC1A3 (Homo sapiens)6480464CTD[Estradiol co-treated with Progesterone] results in increased expression of SLC1A3 mRNAPMID:20660070
Slc1a3multiple interactionsISOSlc1a3 (Mus musculus)6480464CTDEstradiol inhibits the reaction [manganese chloride results in decreased expression of SLC1A3 mRNA]; Estradiol inhibits the reaction [manganese chloride results in decreased expression of SLC1A3 protein]PMID:29183790
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