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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3535
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rarb
Name: retinoic acid receptor, beta
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rarbdecreases expressionISORARB (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of RARB mRNAPMID:10673743
Rarbmultiple interactionsISORarb (Mus musculus)6480464CTDArsenic Trioxide inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]PMID:15688020
Rarbmultiple interactionsISORARB (Homo sapiens)6480464CTDArsenic Trioxide inhibits the reaction [PRAM1 protein results in decreased expression of RARB mRNA]; Arsenic Trioxide inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]; Arsenic Trioxide inhibits the reaction [Tretinoin results in increased expression of RARB protein]PMID:11133770 PMID:16184197 PMID:18941112
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