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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3434
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptger1
Name: prostaglandin E receptor 1
Acc ID: CHEBI:254496
Term: 7,12-dimethyltetraphene
Definition: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.
Chemical ID: MESH:D015127
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptger1increases response to substanceISOPtger1 (Mus musculus)6480464CTDPTGER1 results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracenePMID:21739481
Ptger1multiple interactionsISOPtger1 (Mus musculus)6480464CTDcelecoxib inhibits the reaction [PTGER1 results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene]; PTGS2 gene mutant form inhibits the reaction [PTGER1 results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene]PMID:21739481
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