Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3370
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppard
Name: peroxisome proliferator-activated receptor delta
Acc ID: CHEBI:29699
Term: tunicamycin
Definition: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.
Chemical ID: MESH:D014415
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppardincreases response to substanceISOPpard (Mus musculus)6480464CTDPPARD gene mutant form results in increased susceptibility to TunicamycinPMID:29289645
Ppardmultiple interactionsISOPpard (Mus musculus)6480464CTD[PPARD gene mutant form results in increased susceptibility to Tunicamycin] which results in increased expression of NQO1 mRNA; [PPARD gene mutant form results in increased susceptibility to Tunicamycin] which results in increased expression of VLDLR mRNA; [PPARD gene mutant form results in increased susceptibility to Tunicamycin] which results in increased phosphorylation of NFE2L2 protein; [PPARD gene mutant form results in increased susceptibility to Tunicamycin] which results in increased uptake of Triglycerides; FGF21 protein inhibits the reaction [Tunicamycin promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR mRNA]]; FGF21 protein inhibits the reaction [Tunicamycin promotes the reaction [PPARD gene mutant form results in increased uptake of Triglycerides]]; PPARD gene mutant form promotes the reaction [Tunicamycin results in increased expression of TRIB3 mRNA]; PPARD gene mutant form promotes the reaction [Tunicamycin results in increased uptake of Triglycerides]; Tunicamycin inhibits the reaction [FGF21 protein inhibits the reaction [PPARD gene mutant form results in increased uptake of Triglycerides]]; Tunicamycin promotes the reaction [PPARD gene mutant form results in increased expression of TRIB3 mRNA]; Tunicamycin promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR mRNA]; Tunicamycin promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR protein]PMID:29289645
Go Back to source page   Continue to Ontology report