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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3369
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppara
Name: peroxisome proliferator activated receptor alpha
Acc ID: CHEBI:27432
Term: alpha-linolenic acid
Definition: A linolenic acid with cis-double bonds at positions 9, 12 and 15. Shown to have an antithrombotic effect.
Chemical ID: MESH:D017962
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pparamultiple interactionsEXP 6480464CTDalpha-Linolenic Acid binds to and results in increased activity of PPARA proteinPMID:16731579
Pparaaffects abundanceISOPpara (Mus musculus)6480464CTDPPARA protein affects the abundance of alpha-Linolenic AcidPMID:23619606
Pparaincreases expressionISOPpara (Mus musculus)6480464CTDalpha-Linolenic Acid results in increased expression of PPARA mRNAPMID:18154422
Pparaincreases expressionISOPPARA (Homo sapiens)6480464CTDalpha-Linolenic Acid results in increased expression of PPARA mRNAPMID:19667161
Pparamultiple interactionsISOPpara (Mus musculus)6480464CTDalpha-Linolenic Acid binds to and results in increased activity of PPARA protein; Diethylhexyl Phthalate inhibits the reaction [PPARA protein affects the abundance of alpha-Linolenic Acid]PMID:16731579 PMID:23619606
Pparamultiple interactionsISOPPARA (Homo sapiens)6480464CTDalpha-Linolenic Acid binds to and results in increased activity of PPARA protein; Calcitriol promotes the reaction [alpha-Linolenic Acid results in increased expression of PPARA mRNA]PMID:10403814 PMID:16731579 PMID:19667161
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