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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3185
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos2
Name: nitric oxide synthase 2
Acc ID: CHEBI:63948
Term: trimethyltin
Definition: An organotin compound that consists of stannane in which three of the four hydrogens are substituted by methyl groups.
Chemical ID: MESH:C046488
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos2increases expressionISONos2 (Mus musculus)6480464CTDtrimethyltin results in increased expression of NOS2 proteinPMID:26756313
Nos2multiple interactionsISONos2 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of NOS2 mRNA]; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of NOS2 mRNA; magnolol inhibits the reaction [trimethyltin results in increased expression of NOS2 protein]; SB 203580 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of NOS2 mRNA]PMID:26756313 PMID:30993381
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