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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2915
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ins1
Name: insulin 1
Acc ID: CHEBI:75253
Term: phenylarsine oxide
Definition: An arsine oxide derived from phenylarsine.
Chemical ID: MESH:C029341
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ins1decreases activityEXP 6480464CTDoxophenylarsine results in decreased activity of INS1 proteinPMID:2262933 PMID:8703991
Ins1decreases degradationEXP 6480464CTDoxophenylarsine results in decreased degradation of INS1 proteinPMID:2645939
Ins1multiple interactionsEXP 6480464CTDDithiothreitol affects the reaction [oxophenylarsine results in decreased activity of INS1 protein]; oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of 3-O-Methylglucose]; oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of Glucose]; oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Glucose]PMID:1847587 PMID:2185640 PMID:2262933 PMID:2645939
Ins1affects bindingISOIns1 (Mus musculus)6480464CTDoxophenylarsine binds to INS1 proteinPMID:1629198
Ins1decreases activityISOIns1 (Mus musculus)6480464CTDoxophenylarsine results in decreased activity of INS1 proteinPMID:2458350 PMID:3882699
Ins1multiple interactionsISOIns1 (Mus musculus)6480464CTDDimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of Deoxyglucose]]; Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]]; oxophenylarsine inhibits the reaction [INS1 protein affects the transport of SLC2A4 protein]; oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of Deoxyglucose]; oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]PMID:1536656 PMID:2202293 PMID:3882699
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