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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:53509
Term: erlotinib hydrochloride
Definition: The hydrochloride salt of erlotinib.
Chemical ID: MESH:D000069347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6increases expressionEXP 6480464CTDErlotinib Hydrochloride results in increased expression of IL6 mRNAPMID:24768708
Il6increases secretionEXP 6480464CTDErlotinib Hydrochloride results in increased secretion of IL6 proteinPMID:24768708
Il6multiple interactionsEXP 6480464CTDDDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in increased expression of IL6 mRNA]; DDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in increased secretion of IL6 protein]PMID:24768708
Il6increases expressionISOIl6 (Mus musculus)6480464CTDErlotinib Hydrochloride results in increased expression of IL6 mRNAPMID:24768708
Il6increases secretionISOIl6 (Mus musculus)6480464CTDErlotinib Hydrochloride results in increased secretion of IL6 proteinPMID:24768708
Il6increases secretionISOIL6 (Homo sapiens)6480464CTDErlotinib Hydrochloride results in increased secretion of IL6 proteinPMID:27738319
Il6multiple interactionsISOIL6 (Homo sapiens)6480464CTDErlotinib Hydrochloride inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased expression of IL6 mRNA]; Erlotinib Hydrochloride inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased secretion of IL6 protein]; Interleukin 1 Receptor Antagonist Protein inhibits the reaction [Erlotinib Hydrochloride results in increased secretion of IL6 protein]PMID:27738319 PMID:30623574
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