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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1
Name: insulin-like growth factor 1
Acc ID: CHEBI:64243
Term: monosodium L-glutamate
Definition: An optically active form of monosodium glutamate having L-configuration.
Chemical ID: MESH:D012970
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1decreases expressionEXP 6480464CTDSodium Glutamate results in decreased expression of IGF1 mRNA; Sodium Glutamate results in decreased expression of IGF1 proteinPMID:10718930 PMID:7533119 PMID:7711889 PMID:8368293
Igf1decreases secretionEXP 6480464CTDSodium Glutamate results in decreased secretion of IGF1 proteinPMID:10718930
Igf1multiple interactionsEXP 6480464CTDGH1 protein inhibits the reaction [Sodium Glutamate results in decreased expression of IGF1 mRNA]; JI-38 inhibits the reaction [Sodium Glutamate results in decreased secretion of IGF1 protein]PMID:10718930 PMID:7711889
Igf1multiple interactionsISOIgf1 (Mus musculus)6480464CTD[Sodium Glutamate co-treated with Azoxymethane] affects the expression of IGF1 mRNAPMID:22223845
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