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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:53001
Term: nickel sulfate
Definition: A metal sulfate having nickel(2+) as the metal ion.
Chemical ID: MESH:C029938
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngaffects expressionISOIFNG (Homo sapiens)6480464CTDnickel sulfate affects the expression of IFNG mRNAPMID:11145678
Ifngincreases expressionISOIfng (Mus musculus)6480464CTDnickel sulfate results in increased expression of IFNG mRNAPMID:16166746
Ifngincreases secretionISOIFNG (Homo sapiens)6480464CTDnickel sulfate results in increased secretion of IFNG proteinPMID:10929769 PMID:14650623 PMID:15270870 PMID:15663561
Ifngmultiple interactionsISOIFNG (Homo sapiens)6480464CTD[nickel sulfate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; Cholecalciferol inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]; Cyclosporine inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]; Dimethyl Fumarate inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]; Hydrocortisone inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]; IFNG protein promotes the reaction [nickel sulfate results in increased expression of IL27 mRNA]; Zinc Sulfate inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]PMID:14650623 PMID:15663561 PMID:29594315 PMID:30421605
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