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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:28001
Term: vancomycin
Definition: A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.
Chemical ID: MESH:D014640
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionEXP 6480464CTDVancomycin results in increased expression of HMOX1 mRNAPMID:18289764
Hmox1decreases expressionISOHmox1 (Mus musculus)6480464CTDVancomycin results in decreased expression of HMOX1 mRNAPMID:18930951
Hmox1multiple interactionsISOHmox1 (Mus musculus)6480464CTD[Vancomycin co-treated with Neomycin co-treated with Metronidazole] promotes the reaction [Zinc Oxide analog results in increased expression of HMOX1 protein]PMID:36535435
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