GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hfe | affects abundance | ISO | HFE (Homo sapiens) | 6480464 | CTD | HFE gene polymorphism affects the abundance of Iron; HFE protein affects the abundance of Iron | PMID:12393473 PMID:16877869 | Hfe | affects abundance | ISO | Hfe (Mus musculus) | 6480464 | CTD | HFE protein affects the abundance of Iron | PMID:18317567 | Hfe | affects metabolic processing | ISO | Hfe (Mus musculus) | 6480464 | CTD | HFE protein affects the metabolism of Iron | PMID:17194590 | Hfe | affects response to substance | ISO | HFE (Homo sapiens) | 6480464 | CTD | HFE protein affects the susceptibility to Iron | PMID:16893896 | Hfe | decreases uptake | ISO | HFE (Homo sapiens) | 6480464 | CTD | HFE protein results in decreased uptake of Iron | PMID:16823846 PMID:16841247 | Hfe | increases abundance | ISO | HFE (Homo sapiens) | 6480464 | CTD | HFE gene mutant form results in increased abundance of Iron; HFE gene polymorphism results in increased abundance of Iron | PMID:17047092 PMID:17101320 | Hfe | increases uptake | ISO | HFE (Homo sapiens) | 6480464 | CTD | HFE gene mutant form results in increased uptake of Iron | PMID:17101320 | Hfe | multiple interactions | ISO | HFE (Homo sapiens) | 6480464 | CTD | [HFE protein binds to B2M protein binds to SLC11A2 protein] which results in decreased uptake of Iron; [HFE protein binds to TFR2 protein] which affects the susceptibility to Iron; HFE protein inhibits the reaction [TFRC protein results in increased uptake of Iron]; TNF gene SNP promotes the reaction [HFE protein mutant form results in increased uptake of Iron] | PMID:10085150 PMID:16793930 PMID:16841247 PMID:16893896 | Hfe | multiple interactions | ISO | Hfe (Mus musculus) | 6480464 | CTD | [HFE gene mutant form co-treated with TFR2 gene mutant form] results in increased abundance of Iron | PMID:22383097 | |
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