Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2790
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Hdc
Name:	histidine decarboxylase

Acc ID:	CHEBI:53556
Term:	toluene 2,4-diisocyanate
Definition:	A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.
Chemical ID:	MESH:D014051

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Hdc	increases activity	EXP		6480464	CTD	Toluene 2,4-Diisocyanate results in increased activity of HDC protein	PMID:18360087
Hdc	increases expression	EXP		6480464	CTD	Toluene 2,4-Diisocyanate results in increased expression of HDC mRNA	PMID:15054596 PMID:18360087 PMID:19050374
Hdc	multiple interactions	EXP		6480464	CTD	Dexamethasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased activity of HDC protein]; Dexamethasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HDC mRNA]; sho-seiryu-to inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HDC mRNA]	PMID:15054596 PMID:18360087 PMID:19050374

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