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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2790
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hdc
Name: histidine decarboxylase
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hdcdecreases activityEXP 6480464CTDDexamethasone results in decreased activity of HDC proteinPMID:17075268
Hdcdecreases expressionEXP 6480464CTDDexamethasone results in decreased expression of HDC mRNAPMID:17075268
Hdcmultiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased activity of HDC protein]; Dexamethasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HDC mRNA]PMID:15054596 PMID:18360087
Hdcmultiple interactionsISOHDC (Homo sapiens)6480464CTDDexamethasone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of and results in increased activity of HDC protein]PMID:27553716
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