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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstp1
Name: glutathione S-transferase pi 1
Acc ID: CHEBI:31823
Term: mercury dichloride
Definition: A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.
Chemical ID: MESH:D008627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstp1increases expressionEXP 6480464CTDMercuric Chloride results in increased expression of GSTP1 mRNAPMID:32599119
Gstp1multiple interactionsEXP 6480464CTD[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GSTP1 mRNA; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GSTP1 proteinPMID:29298499
Gstp1affects response to substanceISOGSTP1 (Homo sapiens)6480464CTDGSTP1 protein SNP affects the susceptibility to Mercuric ChloridePMID:22401947
Gstp1multiple interactionsISOGSTP1 (Homo sapiens)6480464CTDMercuric Chloride inhibits the reaction [GSTP1 protein SNP binds to and results in increased glutathionylation of Dinitrochlorobenzene]PMID:22401947
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