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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2753
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsta1
Name: glutathione S-transferase alpha 1
Acc ID: CHEBI:47519
Term: ketoconazole
Definition: A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
Chemical ID: MESH:D007654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsta1multiple interactionsEXP 6480464CTDKetoconazole inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSTA1 mRNA]; Ketoconazole inhibits the reaction [Genistein results in increased expression of GSTA1 mRNA]PMID:31168027 PMID:32185415
Gsta1decreases expressionISOGSTA1 (Homo sapiens)6480464CTDKetoconazole results in decreased expression of GSTA1 mRNAPMID:16608920
Gsta1multiple interactionsISOGSTA1 (Homo sapiens)6480464CTDKetoconazole inhibits the reaction [Phenobarbital results in increased expression of GSTA1 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of GSTA1 mRNA]PMID:16608920
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