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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2722
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Got2
Name: glutamic-oxaloacetic transaminase 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Got2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of GOT2 mRNAPMID:34947998
Got2increases expressionEXP 6480464CTDbisphenol A results in increased expression of GOT2 mRNAPMID:25181051
Got2decreases expressionISOGOT2 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of GOT2 proteinPMID:34186270
Got2increases expressionISOGOT2 (Homo sapiens)6480464CTDbisphenol A results in increased expression of GOT2 proteinPMID:37567409
Got2increases methylationISOGOT2 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of GOT2 genePMID:31601247
Got2multiple interactionsISOGOT2 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] affects the methylation of GOT2 genePMID:31601247
Got2multiple interactionsISOGot2 (Mus musculus)6480464CTD[Dietary Sucrose co-treated with Dietary Fats co-treated with bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of GOT2 mRNAPMID:30722647
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