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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2668
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gcg
Name: glucagon
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gcgincreases expressionISOGcg (Mus musculus)6480464CTDdeoxynivalenol results in increased expression of GCG proteinPMID:28633506
Gcgincreases secretionISOGcg (Mus musculus)6480464CTDdeoxynivalenol results in increased secretion of GCG protein alternative formPMID:25787141
Gcgmultiple interactionsISOGcg (Mus musculus)6480464CTD1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form]; 2-aminoethyl diphenylborinate inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form]; Egtazic Acid inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form]; Nitrendipine inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form]; triphenylphosphine oxide inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form]PMID:25787141
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