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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2559
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Epo
Name: erythropoietin
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Epodecreases expressionEXP 6480464CTDHydrogen Peroxide results in decreased expression of EPO proteinPMID:9927288
Epomultiple interactionsEXP 6480464CTDVitamin A inhibits the reaction [Hydrogen Peroxide results in decreased expression of EPO protein]PMID:9927288
Epodecreases expressionISOEPO (Homo sapiens)6480464CTDHydrogen Peroxide results in decreased expression of EPO proteinPMID:7980410
Epomultiple interactionsISOEpo (Mus musculus)6480464CTDEPO protein inhibits the reaction [GCH1 gene mutant form results in increased abundance of Hydrogen Peroxide]; Hydrogen Peroxide inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]PMID:10756076 PMID:25490417
Epomultiple interactionsISOEPO (Homo sapiens)6480464CTD[Amitrole results in increased abundance of Hydrogen Peroxide] which results in decreased expression of EPO protein; [Vitamin K 3 results in increased abundance of Hydrogen Peroxide] which results in decreased expression of EPO protein; CAT protein inhibits the reaction [Hydrogen Peroxide results in decreased expression of EPO protein]PMID:7980410
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