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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2503
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:29699
Term: tunicamycin
Definition: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.
Chemical ID: MESH:D014415
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1increases expressionISONqo1 (Mus musculus)6480464CTDTunicamycin results in increased expression of NQO1 mRNA; Tunicamycin results in increased expression of NQO1 proteinPMID:22959925 PMID:29289645 PMID:30253173
Nqo1increases expressionISONQO1 (Homo sapiens)6480464CTDTunicamycin results in increased expression of NQO1 mRNAPMID:36586010
Nqo1multiple interactionsISONqo1 (Mus musculus)6480464CTD[PPARD gene mutant form results in increased susceptibility to Tunicamycin] which results in increased expression of NQO1 mRNA; Exenatide inhibits the reaction [Tunicamycin results in increased expression of NQO1 mRNA]; NFE2L2 mRNA affects the reaction [Tunicamycin results in increased expression of NQO1 mRNA]PMID:22959925 PMID:29289645 PMID:30253173
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