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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2456
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:53001
Term: nickel sulfate
Definition: A metal sulfate having nickel(2+) as the metal ion.
Chemical ID: MESH:C029938
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1decreases expressionEXP 6480464CTDnickel sulfate results in decreased expression of CYP17A1 mRNA; nickel sulfate results in decreased expression of CYP17A1 proteinPMID:29567110
Cyp17a1multiple interactionsEXP 6480464CTD[CGA protein co-treated with nickel sulfate] results in decreased expression of CYP17A1 mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of CYP17A1 protein; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]; U 0126 inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; U 0126 inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]PMID:29567110
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