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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2396
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cpt1a
Name: carnitine palmitoyltransferase 1A
Acc ID: CHEBI:5001
Term: fenofibrate
Definition: A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.
Chemical ID: MESH:D011345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cpt1aincreases expressionEXP 6480464CTDFenofibrate results in increased expression of CPT1A mRNAPMID:16595124 PMID:27665778 PMID:32741897
Cpt1aincreases expressionISOCpt1a (Mus musculus)6480464CTDFenofibrate results in increased expression of CPT1A mRNAPMID:17118139 PMID:19124612
Cpt1aincreases expressionISOCPT1A (Homo sapiens)6480464CTDFenofibrate results in increased expression of CPT1A mRNAPMID:17070643 PMID:25572481 PMID:30611848
Cpt1amultiple interactionsISOCpt1a (Mus musculus)6480464CTDFenofibrate inhibits the reaction [zoledronic acid results in decreased expression of CPT1A mRNA]PMID:28871336
Cpt1amultiple interactionsISOCPT1A (Homo sapiens)6480464CTDFenofibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of CPT1A protein]; Fenofibrate promotes the reaction [Fatty Acids, Nonesterified results in increased expression of CPT1A mRNA]; Fenofibrate promotes the reaction [Oleic Acid results in increased expression of CPT1A mRNA]PMID:24534255 PMID:24735863 PMID:32613381
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