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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2396
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cpt1a
Name: carnitine palmitoyltransferase 1A
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cpt1aaffects expressionISOCPT1A (Homo sapiens)6480464CTDBenzo(a)pyrene affects the expression of CPT1A mRNAPMID:25690898
Cpt1aaffects methylationISOCPT1A (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of CPT1A 5' UTR; Benzo(a)pyrene affects the methylation of CPT1A promoterPMID:27901495
Cpt1adecreases expressionISOCPT1A (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of CPT1A proteinPMID:32717239
Cpt1aincreases expressionISOCpt1a (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CPT1A mRNAPMID:19770486
Cpt1aincreases expressionISOCPT1A (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of CPT1A mRNAPMID:21632981 PMID:21871943 PMID:22316170
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