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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2396
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cpt1a
Name: carnitine palmitoyltransferase 1A
Acc ID: CHEBI:15354
Term: choline
Definition: A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.
Chemical ID: MESH:D002794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cpt1amultiple interactionsISOCpt1a (Mus musculus)6480464CTD[3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in decreased expression of CPT1A mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in decreased expression of CPT1A mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with aroclor 1260] results in decreased expression of CPT1A mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with aroclor 1260] results in increased expression of CPT1A mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with RXRA gene mutant form] results in decreased expression of CPT1A mRNA; [Methionine deficiency co-treated with Choline deficiency] results in decreased expression of CPT1A mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of CPT1A mRNA; alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of CPT1A mRNA]; Chenodeoxycholic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of CPT1A mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of CPT1A mRNA]]; Tamoxifen inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CPT1A mRNA]PMID:18952117 PMID:23038002 PMID:27773935 PMID:28163111 PMID:28973532
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