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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2increases expressionEXP 6480464CTDPhenobarbital results in increased expression of ABCC2 mRNA; Phenobarbital results in increased expression of ABCC2 proteinPMID:11328961 PMID:15908472 PMID:18473823 PMID:19162173 PMID:19631232 PMID:21318169 PMID:22037397 PMID:22659317
Abcc2multiple interactionsEXP 6480464CTDKN 62 inhibits the reaction [Phenobarbital results in increased expression of ABCC2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenobarbital results in increased expression of ABCC2 protein]PMID:18473823
Abcc2affects expressionISOAbcc2 (Mus musculus)6480464CTDPhenobarbital affects the expression of ABCC2 mRNAPMID:23091169
Abcc2affects expressionISOABCC2 (Homo sapiens)6480464CTDPhenobarbital affects the expression of ABCC2 mRNAPMID:19159669
Abcc2increases expressionISOAbcc2 (Mus musculus)6480464CTDPhenobarbital results in increased expression of ABCC2 mRNA; Phenobarbital results in increased expression of ABCC2 proteinPMID:15986414 PMID:19270015 PMID:27160211
Abcc2increases expressionISOABCC2 (Homo sapiens)6480464CTDPhenobarbital results in increased expression of ABCC2 mRNA; Phenobarbital results in increased expression of ABCC2 proteinPMID:16837569 PMID:19084549 PMID:35881160
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