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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:38221
Term: fumonisin B1
Definition: A diester that results from the condensation of the 1-carboxy groups of two molecules of propane-1,2,3-tricarboxylic acid with hydroxy groups at positions 14 and 15 of (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol.
Chemical ID: MESH:C056933
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3decreases expressionISOCasp3 (Mus musculus)6480464CTDfumonisin B1 results in decreased expression of CASP3 mRNAPMID:35697133
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDfumonisin B1 results in increased expression of CASP3 mRNAPMID:31891755
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTD[fumonisin B1 co-treated with ochratoxin A] results in increased cleavage of CASP3 protein; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP3 mRNA]PMID:36397609
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDfumonisin B1 results in decreased expression of and results in increased cleavage of CASP3 proteinPMID:31891755
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